Influence of Growth Factors on Tissue-Engineered Pediatric Elastic Cartilage
نویسندگان
چکیده
منابع مشابه
A Review Study: Effect of Growth Factors on Human Mesenchymal Stem Cells Differentiation into Cartilage Tissue
Hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. After some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. Currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. In this regard, tissue&...
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OBJECTIVE To evaluate the feasibility of in vitro fabrication of tissue-engineered cartilage from human nasoseptal chondrocytes for autologous reconstruction. DESIGN Hyaline cartilage was reconstituted from chondrocyte-polyglycolic acid scaffolding constructs in a 3-dimensional mammalian cell culture cascade. This included monolayer cellular amplification, cell seeding in the spinner flask, a...
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Introduction: A fundamental challenge of cartilage tissue engineering has been the inability to promote collagen synthesis up to native levels [1]. In contrast, recent protocols have demonstrated that glycosaminoglycans can be synthesized to native levels in 4 to 6 weeks of in vitro culture [2]. We hypothesize that rapid GAG synthesis may be an impediment to collagen synthesis, possibly by alte...
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A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with advective and diffusive solute transport, uptake and biosynthesis. To illustrate the approach we focused on the synthesis an...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2000
ISSN: 0886-4470
DOI: 10.1001/archotol.126.10.1234